We will review some of the main evidence for dark matter at cosmological and galactic scales as well as the lessons that nature has provided to us in the light of no solid signals in the search for direct and indirect signatures of dark matter particles. We will see that dark matter research is a multidisciplinary endeavor since it might be connected to the origin of cancer in humans, global warming, solar physics etc. Lastly, we will introduce a new test to possibly unveil the nature of dark matter once for all.